Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: A Mendelian randomization study

JS Ong; LD Hwang; G Cuellar-Partida; NG Martin; G Chenevix-Trench; MCJ Quinn; MC Cornelis; P Gharahkhani; PM Webb; S MacGregor; E Bryne; PA Fasching; A Hein; S Burghaus; MW Beckmann; D Lambrechts; E Van Nieuwenhuysen; I Vergote; A Vanderstichele; AJ Swerdlow; M Jones; N Orr; M Schoemaker; DV Edwards; J Brenton; J Benítez; MJ García; CR Rodriguez-Antona; MA Rossing; RT Fortner; E Riboli; J Chang-Claude; U Eilber; S Wang-Gohrke; D Yannoukakos; MT Goodman; N Bogdanova; T Dörk; M Duerst; P Hillemanns; IB Runnebaum; N Antonenkova; R Butzow; H Nevanlinna; LM Pelttari; RP Edwards; JL Kelley; F Modugno; KB Moysich; RB Ness; R Cannioto; F Heitz; B Karlan; H Olsson; SK Kjaer; A Jensen; GG Giles; F Bruinsma; MAT Hildebrandt; D Liang; X Wu; L Le Marchand; VW Setiawan; JB Permuth; M Bisogna; F Dao; DA Levine; DW Cramer; KL Terry; SS Tworoger; M Stampfer; W Willet; S Missmer; L Bjorge; RK Kopperud; K Bischof; LC Vestrheim Thomsen; LA Kiemeney; LFAG Massuger; T Pejovic; A Brooks-Wilson; SH Olson; V McGuire; JH Rothstein; W Sieh; AS Whittemore; LS Cook; ND Le; C Blake Gilks; J Gronwald; A Jakubowska; J Lubiński; T Kluz; N Wentzensen; L Brinton; B Trabert; J Lissowska; E Høgdall; CK Høgdall; DP Sandler

Journal article

Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: A Mendelian randomization study

JS Ong, LD Hwang, G Cuellar-Partida, NG Martin, G Chenevix-Trench, MCJ Quinn, MC Cornelis, P Gharahkhani, PM Webb, S MacGregor, E Bryne, PA Fasching, A Hein, S Burghaus, MW Beckmann, D Lambrechts, E Van Nieuwenhuysen, I Vergote, A Vanderstichele, AJ Swerdlow Show all

International Journal of Epidemiology | OXFORD UNIV PRESS | Published : 2018

DOI: 10.1093/IJE/DYX236

Abstract

Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using aWald-type ratio estimator. Results: For all EOC cases, the causal odds ratio ..

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